Date, time and coverage: Wednesday 30 January, 20:00 GMT. The match, a sell-out, will not be broadcast live on UK television. You can follow the action live via ManUtd.com’s radio and text commentary.
Form guide: United are on an 11-game unbeaten streak and looked constantly menacing during the weekend's resounding FA Cup win over Fulham. The Reds have also won the last seven games against Southampton, including this season's 3-2 thriller at St Mary's. The Saints arrive at Old Trafford in better shape than you may think: they've lost just once in their last seven games, although five of those fixtures ended in draws.
Betting: Despite Southampton's promising recent form, bwin make the south-coast side 21/2 to win at Old Trafford. Bookies are offering just 1/5 on a Reds win, with the draw priced at 23/4.
Ins and outs: United came through the weekend unscathed and there's good news for Nick Powell fans, as the youngster has resumed training following a recent knock. This match will probably come too soon for both Ashley Young (knee) and Jonny Evans (hamstring), however. Southampton will sweat on the fitness of Adam Lallana, while striker Guilhermo do Prado and defender Jose Fonte are almost certain to miss the clash. All three players have been out with knee injuries.
Last meeting: Southampton were in dreamland back in September when they took a two-goal lead at St Mary's. But along came Robin van Persie to rescue the Reds with a superb hat-trick, including a 90th-minute winner. Bizarrely, though, the Dutchman wasn't even the best player on the pitch that day. That honour went to Paul Scholes, who pulled all the strings in midfield.
Did you know? Each of the last five fixtures between United and Southampton have been played at St Mary's. Old Trafford